Role OF Geometric Mean in Estimation of Differential Renal Function in DMSA Scintigraphy .

Document Type : Original Article

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Oncology Department, Unit of Nuclear Medicine, Faculty of Medicine, Sohag University, Egypt

Abstract

Background: Renal scintigraphy was used to evaluate the relative renal function employing a specialized camera (Gamma camera), a computer, and variety of radiopharmaceuticals, including technetium-99m dimercaptosuccinic acid (99mTc-DMSA), technetium-99m diethylenetriaminepentaacetic acid (99mTc-DTPA), technetium-99m mercaptoacetyltriglycine (99mTc MAG3), iodine 131 orthoiodohippurate (OIH), and more recently, technetium-99m ethylenedicysteine (99mTc-EC), renal scintigraphy was utilized to assess the relative renal function. Objective: to determine if there were any significant differences between results from the geometric mean and posterior counts alone for measuring relative renal function. Methods: One hundred and fifty-eight DMSA scans performed from May 2022 to May 2023 were studied in This Randomized controlled clinical study (simple randomization) performed in the nuclear medicine unit of Sohag Oncology Institute. About twenty patients were excluded for having a single kidney. To assess the impact of the geometric mean calculation on patients of varying ages, patients were split into two age groups: group I, who were under 18, and group II, who were at least 18 years old. Results: The two methods were compared regarding age, gender, and presented renal pathologies. Regarding age and gender, our study reveals no statistically significant difference between the two methods, with P values of 0.364 and 0.971, respectively. Conclusions: Differential renal function (DRF) measurements using the geometric mean approach are as accurate as those using the posterior view method. There was a significant difference between the two methods regarding the criteria of >5% variance rate with different renal pathologies (P Value 0.004) our study concluded patients with ectopic and horse-shoe kidneys as well as other pathologies with normally located kidneys.

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