Role of diffusion tensor imaging biomarkers and tractography to predict motor outcomes in patients with cerebral ischemic infarctions.

Articles in Press

Document Type : Original Article

Authors

1 2 El-Rahma street, Minia, Egypt

2 Radiology department, faculty of medicine, Minia University.

3 Radiology department, faculty of medicine. Minia university

4 Radiology department. faculty of medicine. Minia university

Abstract

Background: Acute ischemic stroke is one of the main causes of death globally. Conventional magnetic resonance techniques cannot provide reliable information regarding the integrity of the white matter tracts limiting its ability to predict the clinical outcome. Prediction of the motor outcome becomes very important to determine a specific rehabilitation strategy and the final clinical outcomes. The purpose of this study was to assess the value of diffusion tensor imaging (DTI) in patients with acute ischemic stroke as a prognostic modality to predict the motor outcome.

Results: A significant statistical association was found between the 3D tractography findings and the NIHSS score on admission and the NIHSS score on recovery after 3 months. Residual neurological deficits were found in patients with disrupted tracts. However, near-complete clinical recovery was found in patients with intact non-disrupted tracts. Also, significant statistical association was found between the degree of FA reduction in the affected tracts and the NIHSS score on admission and the NIHSS score on recovery after 3 months.

Conclusion: DTI is a technique that can detect the microstructural changes in the white matter tracts affected by ischemic lesions, as a result, it can be used as a tool to predict motor outcomes in patients with acute stroke and help in determining the best rehabilitation strategy.

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Minia Journal of Medical Research

Articles in Press, Accepted Manuscript
Available Online from 11 August 2024

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