Study of Immunohistochemical Expression of NUSAP1 in Clear Cell Renal Cell Carcinoma

Articles in Press

Document Type : Original Article

Authors

1 Pathology department, Faculty of medicine, Minia University, Minia, Egypt

2 Pathology department, Minia University, Minia, Egypt

3 Department of Pathology, Faculty of Medicine, Minia University, Minia, Egypt

4 Department of pathology, Faculty of Medicine, Minia University, Egypt

Abstract

Introduction: Globally, renal cell carcinoma (RCC) is among the most prevalent malignancies. A mixture of genetic mutations and environmental influences are the main causes. NUSAP1 is an anti-apoptotic marker which enhances cellular invasion and migration via a variety of pathways, including PI3K/AKT/mTOR pathway. NUSAP1 has been shown to be significantly expressed in variety of tumours, but little is known about its implications in ccRCC.

Aim of work: to assess the IHC expressions of NUSAP1 and investigate the relationship between NUSAP1 expression and various clinical and pathological characteristics of cases of ccRCC.



Methods: Fifty tissue specimens of ccRCC were subjected to IHC staining procedure of NUSAP1 utilizing the avidin biotin-peroxidase method in conjunction with chromagen detection in order to look into how clinicopathological data and NUSAP1 expression relate to one another.



Results: In 60% of instances, there was evidence of prominent NUSAP1 expression. A statistically positive correlation was observed between the expression of NUSAP1 and tumor stage (p=0.003), Fuhrman grade (p=0.022), and distant metastases (p=0.007).



Conclusion: In ccRCC, NUSAP1 expression may be regarded as a negative predictive factor.



Keywords: Renal cell carcinoma, NUSAP1, IHC.



There is no conflict of interest among authors.

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Minia Journal of Medical Research

Articles in Press, Accepted Manuscript
Available Online from 29 July 2024

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