Effect of Diabetes Mellitus on Oxidative Stress and Inflammatory Markers in Parkinson's Adult Male Albino Rats

Document Type : Original Article

Authors

1 Department of medical physiology, faculty of medicine, minia university, minia city, Egypt

2 physiology department, faculty of medicine, Minia university

3 Department of Medical Physiology, Faculty of Medicine, Minia University, Minia, Egypt

Abstract

Background : Diabetes mellitus (DM) is a chronic metabolic condition defined by persistent hyperglycemia . Parkinsonism is a clinical syndrome with bradykinesia, static tremors, rigidity, and postural instability. Parkinson's disease is a neurological condition that progresses progressively over time. As people age, it becomes more common. Clinical symptoms remain the primary determinant of PD diagnosis.

Aim and Objectives: This study aims to detect the effect of diabetes mellitus on model of Parkinson's disease (PD) in adult albino rats.

Material and Methods: This study was a prospective controlled experiment done in the laboratory of the Medical Physiology department, under the college of Medicine at Minia University. The experiment involved a collective of 30 rats.

Results: The diabetic Parkinson's group exhibited a statistically significant deterioration in Malondialdehyde (MDA) , Total antioxidant capacity (TAC), and Tumor necrosis factor-alpha (TNF-α) compared to the control group (C group), Parkinson's group (P group), and Diabetes Parkinson's group (DP group). Conclusion: Diabetes mellitus has a worsening effect on Parkinson’s disease.

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Minia Journal of Medical Research

Articles in Press, Accepted Manuscript
Available Online from 24 March 2024

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