Diagnostic Role and Prognostic Significance of miRNA-133a in Acute Myocardial Infarction

Document Type : Original Article

Authors

1 Department of cardiology , Faculty of Medicine, Minia University

2 Prof. of Cardiology Faculty of Medicine , Minia University

3 Prof. of Cardiology, Faculty of Medicine, Minia University

4 Prof. of Clinical Pathology, Faculty of Medicine, Minia University

5 Associate Professor of Cardiology, Faculty of Medicine, Minia University

Abstract

Background: Despite improvement in acute ST elevation myocardial infarction (STEMI)) therapy, 30% of patients have LV remodeling after myocardial infarction (MI) . It was discovered that miRNA-133a, plays a role in the initial pathophysiology of MI .

Objectives: to evaluate diagnostic and prognostic role of miRNA-133a in STEMI.

Methods: a prospective study that was conducted during 1.5 years. It had two groups: Group I which consisted of 100 patients with acute STEMI, all managed by 1ry PCI , and Group II (n=50) as controls .They underwent comprehensive clinical evaluation, laboratory testing for miRNA-133a , serum high sensitivity cardiac troponin and 2D echocardiographic examination. after 6 months follow up , Group I was divided into subgroup I with LV remodeling based on  20 increase in LVED volume after 6 months and IB without LV remodeling and again was subdivided according to the occurrence of the major adverse cardiovascular events (MACE) during 6-months follow-up.

Results: Group I showed significantly higher levels of miRNA-133a expression (44.22 ± 10.98 vs. 4.31 ± 1.58, p 0.001) than group II. The level of miRNA-133a was not significantly different in patients with LV remodeling and patients with early and late complications. According to a multivariate analysis, LVED was the best predictor of LV remodeling.







Conclusions: miRNA-133 a was found to be a better diagnostic biomarker for Acute STEMI .It could neither predict myocardial remodeling, nor early or late complications as well as fate of the patients after acute STEMI.

Keywords

Main Subjects

Minia Journal of Medical Research

Articles in Press, Accepted Manuscript
Available Online from 24 March 2024

Files

Share

How to cite

Statistics