Serum Levels of Nitric Oxide in Lichen Planus Patients

Document Type : Original Article

Authors

1 Department of Dermatology, STDs & Andrology, Faculty of Medicine, Minia University,Minia, Egypt.

2 Department of dermatology , venereology and STDs faculty of medicin minia universty

3 Department of dermatology,venereology and STDs Minia universty faculty of medecin

4 Department of Biochemistry- Faculty of Medicine- Minia University-Minia.

Abstract

Background: Lichen planus (LP) is an inflammatory condition characterized by the presence of little raised lesions on the skin, mucous membranes, hair, and nails. The overall prevalence is around 1% of the population.

Aims and objectives: To evaluate serum nitric oxide (NO) levels in LP and its relation with LP symptoms and duration and the course of the disease.

Patient and methods: This case-control research involved 20 Egyptian subjects who were recruited from the Outpatient Clinic of the Dermatology and Venerology department, Minia University Hospital from the first of June 2022 to the end of January 2023. They were divided in 2 equal groups; group I included 10 patients with LP and the other 10 subjects served as age-matched normal volunteers.

Results: There was a statistically significant greater levels of NO in cases with LP when compared with the control group. NO serum level correlated with symptoms, severity as well as the duration of the disease.

Conclusion: The properties of NO in the stimulation mechanism of lymphocytes and the cellular immune system closely resemble the development of LP. NO may potentially contribute to the development of LP. Consequently, the utilization of antioxidant medications might be regarded as a potential therapy for LP.

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Minia Journal of Medical Research

Articles in Press, Accepted Manuscript
Available Online from 12 March 2024

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