Effect of Sacubitril/Valsartan on heart rate turbulence in patients with heart failure with reduced ejection fraction

Document Type : Original Article

Authors

1 Department of cardiology, faculty of medicine, Minia university, Minia, Egypt

2 cardiology department,Minia university, Egypt

3 cardiology department,faculty of medicine ,Minia university

4 cardiology department ,faculty of medicine ,minia university

Abstract

Abstract

Background: HRT is noninvasive tool that predicts sudden cardiac death and arrhythmic events in patients with heart failure with reduced ejection fraction



Aim: the current study aimed to know the effect of sacubitril / valsartan drug (Entresto) on the (HRT) in the patients with heart failure with reduced ejection fraction (EF ≤ 35 %).



Methods: We included 42 patients with heart failure with reduced ejection fraction (EF ≤35 %). Patients with normal sinus rhythm and at least 5 PVCs fulfilling the criteria for measurement of HRT in Holter.

A comparative study was done between HRT parameters before and 3 months after sacubitril / valsartan treatment.



Results: We found that HRV index, mean HR, Maximum HR and total number of beats in 24 hrs. were improved after 3 months of sacubitril/ valsartan treatment

HRT score did not improve but it predicted development of complications .



Conclusion: Although HRT score did not improve after 3 months of sacubitril/ valsartan, HRT could predict development of complications such as sudden death , VT , Runs of salvos and PVCs more than 10% .

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Minia Journal of Medical Research

Articles in Press, Accepted Manuscript
Available Online from 26 February 2024

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