Document Type : Original Article
Authors
1
Intenal medicine, Faculty of medicine, Minia universty, Minia, Egypt
2
Internal medicine, Faculty of medicine,Minia unevirsty, Minia, Egypt
3
Nephrology unit, Department of Internal Medicine, Faculty of Medicine -Minia University
4
Department of Clinical Pathology, Faculty of Medicine, Minia University, El-Minia, Egypt
5
Endocrinology and Diabetes unit, Internal medicine department, Faculty of medicine, Minia university.
Abstract
Background: Chronic renal disease-MBD is characterized by irregularities in the metabolism of calcium, phosphorus, PTH, or vitamin D, and abnormalities in mineralization, bone turnover, and the calcification of soft tissues or blood vessels (1). Serum parathormone or bone-specific alkaline phosphatase measurements can be utilized to evaluate bone disease, as elevated or diminished values indicate underlying bone turnover (2). Methods: The study included ninety patients with end stage renal disease (ESRD) undergoing regular hemodialysis at the hemodialysis unit at El-Minia University Hospital. After obtaining informed consent, laboratory tests conducted, including a complete blood count, blood sugar, lipid profile, CRP, blood urea, serum creatinine, albumin, total calcium, phosphate, bone specific alkaline phosphatase, and PTH level evaluation. Results: Hyper-parathyroid bone disease was prevalent in 23.3% of the studied patients and low parathyroid level in 10% of the studied patients and Serum calcium and bone-specific alkaline phosphate levels show high significant correlation with PTH level. Symptoms of MBD were common in both low and high bone turnover populations. According to the study, 57% of the individuals had hypocalcemia. In 66.7% of the patients, PTH was within the regulated range. Conclusion: Depending on abnormal PTH levels (23.3% of patients with high PTH levels and 10% with low PTH levels), the percentage of MBD among the HD patients under study was 33.3%. The majority of patients with low PTH levels had high serum Ca and low bone specific alkaline phosphatase. Patients with high PTH levels had low serum Ca and high bone specific alkaline phosphatase.
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