Document Type : Original Article
Authors
1
rheumatology, rehabilitation and phsical medicine, faculty of medicine, minia unversity, egypt.
2
Rheumatology and rehabilitation department, faculty of medicine, Minia university, Egypt
Abstract
Objective: Determine the pattern of muscle involvement clinically, neurophysiology and laboratory in systemic lupus erythematous and Correlating clinical, function, laboratory finding.
Methods: We gathered patients with systemic lupus erythematoses who involved or did not involve muscles. Clinical examination, functional testing (such as ALT, AST, CPK, Alkaline phosphatase, and aldolase), nerve conduction studies (NCS), electromyography (EMG), and muscle biopsy were used to evaluate them. The outcomes were contrasted with sex- and age-matched healthy controls.
Results: During the study period, thirty patients underwent muscle biopsy, electromyography (EMG), nerve conduction studies (NCS), and laboratory testing. Musculoskeletal symptoms included arthralgia (25 patients), arthritis (16 patients), myalgia (17 patients), mucocutaneous symptoms (malar rash (30), alopecia (6), discoid (3), oral ulcer (11), photosensitivity (9)), chest symptoms (ILD) (11) and central nervous system (CNS) (3). Out of the SLE patients, 1 (3.3%) had clinical muscle weakness. Muscle biopsy affection was 15(50%) and EMG muscle affection was 15% in SLE patients. Clinical, serological, and laboratory differences between patient groups with and without myositis were not statistically significant.
Conclusion; The patient's age and sex with hemoglobin and TLC, as well as their age and the length of their illness with increased insertional activity, were the only two variables that showed a statistically significant positive correlation (p=0.055, p=0.020, respectively). Clinical and laboratory characteristics did not significantly differ between patients with and without myositis. Muscle biopsy affection affected 15% of SLE patients, while EMG muscle affection affected 15% of patients. obtained treatment and whether or not myositis is evident.
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