The possible effects of Zinc sulfate on adult rat olfactory mucosa. A histological study

AbdelHaleem, Aliaa Hamdy; Behery, Amira Fathy; Ibrahim, Randa Ahmed; Abdel Hafez, Sara Mohamed Naguib; Ali, Azza Hussein

doi:10.21608/mjmr.2023.249344.1542

The possible effects of Zinc sulfate on adult rat olfactory mucosa. A histological study

Document Type : Original Article

Authors

¹ Histology and Cell biology Department, faculty of Medicine, Minia University, Minia, Egypt

² Department of Histology and Cell Biology, Faculty of Medicine, Minia University, Minia, Egypt

³ Histology and cell biology, faculty of medicine, Minia University, Minia., Egypt

⁴ Histology and cell biology department Faculty of medicine Minia university, Minia, Egypt

10.21608/mjmr.2023.249344.1542

Abstract

Abstract:

Background: Zinc (Zn) is a well-known trace element that helps regulate a variety of physiological activities. Zinc sulfate (ZnS) is an inorganic chemical, commonly used in zinc insufficiency therapy. Previously oral Zinc supplementation was found to help shorten length of the common cold; however, intranasal Zinc use has been linked to anosmia, or loss of smell, in humans.

Aims of work: This work aims to assess possible effects of ZnS induced toxicity on adult male albino rat olfactory mucosal histological structure.

Methods: Twenty rats were equally allocated into two groups: Control group (C- group) and Zinc sulfate (ZnS) group (given intranasally as 10% ZnS solution).Olfactory mucosa was processed for histological study.

Results: ZnS group showed marked structural alterations in olfactory mucosa in the form of thinning, desquamation of olfactory epithelium and degeneration of both nerve bundles Bowmans glands in the lamina propria.

Conclusion: Zinc sulfate produced destruction of olfactory mucosa in adult male albino rats.

Keywords: Zinc, anosmia, olfactory

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Main Subjects