Background: Thyroid cancer (TC) is the most common type of malignant endocrine cancer and it's ranked as the 10th most common cancer worldwide, and its incidence increases, due to improvement of diagnostic procedures. Papillary thyroid cancer (PTC) is the most frequent type of differentiated thyroid carcinoma. In Egypt PTC subtype represents 85% of all TC cases. SIX1 is expressed in a wide range of normal and neoplastic tissues and it has different pathways in tumorigenesis in different tissues. SIX1 is upregulated in human thyroid cancer cell and promoted cell proliferation and invasion.
Aim of the work: this study was conducted to research the association between SIX1 expression and the clinicopathological features of PTC.
Material and Methods: Immunohistochemical staining of SIX1 was conducted on 50 randomly chosen tissue specimens of PTC 34 (68%) were classic PTC and 16 (32%) were follicular subtype, that was done by using the avidin biotin-peroxidase complex method with diaminobenizidine (DAB) chromogen detection system.
Results: High SIX1 expression was detected in 36% of cases. SIX1 expression showed statistically significant correlation with tumor focality (P= 0.003), lymph node metastasis (P= 0.002), tumor grade (P= 0.002), advanced tumor stage (P= 0.01) assessed by pT staging system, tumor necrosis (P= 0.002), lymphovascular, perineural invasion, and extra thyroidal extension (P= 0.002), (P= 0.01) and (P= 0.001) respectively.
Conclusions: SIX1 expression is significantly associated with poor prognostic factors and thus can be used as a prognostic indicator for PTC patients.
Yehia, A., Gayyed, M., & Abdel Zaher, A. (2024). Immunohistochemical Expression of SIX1 in Papillary Thyroid Carcinoma. Minia Journal of Medical Research, (), -. doi: 10.21608/mjmr.2024.259835.1591
MLA
Aya Fathy Yehia; Mariana Gayyed; Azza Mohamed Abdel Zaher. "Immunohistochemical Expression of SIX1 in Papillary Thyroid Carcinoma". Minia Journal of Medical Research, , , 2024, -. doi: 10.21608/mjmr.2024.259835.1591
HARVARD
Yehia, A., Gayyed, M., Abdel Zaher, A. (2024). 'Immunohistochemical Expression of SIX1 in Papillary Thyroid Carcinoma', Minia Journal of Medical Research, (), pp. -. doi: 10.21608/mjmr.2024.259835.1591
VANCOUVER
Yehia, A., Gayyed, M., Abdel Zaher, A. Immunohistochemical Expression of SIX1 in Papillary Thyroid Carcinoma. Minia Journal of Medical Research, 2024; (): -. doi: 10.21608/mjmr.2024.259835.1591
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