R Effect of STZ- induced Diabetes on Retina of Adult Male Albino Rat.

Document Type : Original Article

Authors

1 faculty of medicine , Histology department

2 department of histology, faculty of medicine, Minia University, Minia, Egypt

3 Minia Faculty of Medicine Minia University

4 department of histology faculty of medicine minia university

Abstract

Background: Vision loss is a possible consequence of diabetic retinopathy (DR), DR is an eye condition linked to diabetes which affect retinal vas-culture. Oxidative stress is the main mechanism of diabetes which causing diabetic retinopathy.

Aim of the work: Investigate the retinal effects of STZ-induced diabetes in albino rats.

Methods: Twenty rats were divided equally into two groups: the control group and the DR group.

Results: The group with DR exhibited a noteworthy reduction in the overall thickness of the retina, along with a disturbed histological structure charac-terized by a destructed photoreceptor layer, visible vacuolation in the nuclear and plexiform layers, and dilated congested blood vessels in the outer nuclear layer (ONL). Also, DR group showed significant increase in blood glucose level compared to control group.

Conclusion: STZ-induced diabetes had an apparent damaging effect on reti-nal tissue through hyperglycemia which cause oxidative stress damage and neovascularization.

Keywords: DM, oxidative stress, neovascularization.

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Minia Journal of Medical Research

Articles in Press, Accepted Manuscript
Available Online from 30 December 2023

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