Right Ventricular Strain Assessment by Speckle Tracking Echocardiography before and after treatment of clinical and subclinical hypothyroidism

Amin, Amr Salah; El Hini, Sahar Hossam; Zaki, Zaki Mohamed; Khaled, Mohamed; Hamdi, Mohammad Hussien; Shehata Mahmoud, Sayed

doi:10.21608/mjmr.2023.254086.1557

Right Ventricular Strain Assessment by Speckle Tracking Echocardiography before and after treatment of clinical and subclinical hypothyroidism

Document Type : Original Article

Authors

¹ cardiology department,faculty of medicine ,Minia university

² Endocrinology and Diabetes unit, Internal medicine department, Faculty of medicine, Minia university

³ Clinical pathology department, faculty of medicine, Minia university, Minia, Egypt

⁴ Cardiology department, Faculty of Medicine, Minia university

⁵ Cardiology department, faculty of medicine, Minia university, Minia, Egypt

⁶ Cardiology department , faculty of medicine , Minia university

10.21608/mjmr.2023.254086.1557

Abstract

Background: Hypothyroidism is prevalent endocrinological disease that raises cardiovascular disorders. Due to the complexity of right ventricular (RV) geometry and its challenging non-invasive testing, speckle tracking echocardiography (STE) emerges as contemporary tool for identifying early changes in RV function.

Aim: RV function evaluation in clinical and subclinical hypothyroidism patients before and after treatment using STE.

Methods: Total 74 individuals underwent for STE. 24 clinical hypothyroidism subjects (group I), 24 subclinical hypothyroidism subjects (group II), and 26 normal individuals as a control group. RV function evaluated prior to the treatment regimen and three months after reaching euthyroid stage.

Results: Prior to therapy, global longitudinal strain (GLS) was significantly lower in patients groups compared with controls. (GLS in group I= -25.2 ± 0.3 Vs. -27.8 ± 0.5 in control group (P value <0.01) and GLS in group II= -25.3 ± 0.2 Vs. -27.8 ± 0.5 in control group (P value <0.01), but no statistically significant difference was found regarding ejection fraction (EF %). After three months at euthyroid stage, the values were not totally reversed but there was significant improvement of GLS, (GLS in group I after treatment= -27.2 ± 0.4 Vs. -25.2 ± 0.3 before treatment (P value <0.05) and GLS in group II after treatment= -27.4 ± 0.2 Vs. -25.3 ± 0.2 before treatment (P value <0.05).

Conclusion: Early detection and treatment of both clinical and subclinical hypothyroidism patients partially reverse RV functional abnormality. STE may efficiently detect early contractile changes, before changes in EF occurs.

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