Revised Carotid Intimal Media Thickness in Type 1 Diabetes Miletus

Document Type : Original Article

Authors

1 Pediatric Minia university

2 Assistant professor of pediatrics, faculty of medicine Minia University

3 Department of Clinical Pathology, Faculty of Medicine, Minia University, El-Minia, Egypt.

Abstract

Introduction: Type 1 diabetes mellitus (T1DM) is characterised by the autoimmune death of pancreatic beta cells, which play a crucial role in the production of insulin. Insulin is a crucial anabolic hormone that has diverse effects on glucose, lipid, protein, and mineral metabolism, in addition to its role in growth.

Insulin assumes a pivotal function in several physiological processes. It facilitates the transfer of glucose into muscle and adipose cells, stimulates the liver to store glucose as glycogen and produce fatty acids, enhances the absorption of amino acids, suppresses the breakdown of fat in adipose tissue, and promotes the uptake of potassium into cells. Individuals who have received a diagnosis of Type 1 Diabetes Mellitus (T1DM) necessitate continuous administration of exogenous insulin throughout their lifetimes. The manifestation of diabetic ketoacidosis (DKA) occurs in the absence of insulin.

Patients and methods: The study was conducted on 60 type 1 DM children and 30 nondiabetic children. Random blood sugar, HbA1c, and carotid intimal medial thickness were assessed in all children.

Results: There were no differences between the diabetic children and controls regarding age, sex, and weight.

Conclusion: Random blood sugar and HbA1c were higher in diabetic patients.

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Minia Journal of Medical Research

Articles in Press, Accepted Manuscript
Available Online from 17 December 2023

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