Effect of doxorubicin on Male Albino Rats' heart:Biochemical and Histological study

Document Type : Original Article

Authors

1 Histology , Faculty of Medicine , Minya university , Elminya Egypt

2 histology department, faculty of medicine, minia university,Minia,Egypt

3 Histology Elminia

4 Histology department Elminia

Abstract

Abstract:

Background:

Drug-induced cardiotoxicity especially the anticancer drugs can be a major cause for limitations of these drugs therapeutic usage. Doxorubicin is one of the most important chemotherapy, it treats many types of cancers but it has toxic effects on heart tissue as it causes oxidative stress ,apoptosis and inflammation and this limits the therapeutic usage of doxorubicin as an anticancer drug.

Aim of the work:

To study the effect of doxorubicin on Albino Rats' heart.

Methods:

Thirty male albino rats were divided equally into two groups: C-group (control group) and B-group ( doxorubicin exposure group).

Measurement of malondialdehyde (MDA) in the heart tissue, an oxidative stress marker, and histological approaches were done.

Results: B-group showed significant increase in MDA levels in cardiomyocytes compared to control group and had degenerative changes in the heart tissue.

Conclusion: Doxorubicin had an apparent damaging effect on cardiac tissue structure by different mechanisms as oxidative stress ,apoptosis and inflammation

Keywords: Cardiotoxicity, DOX , MDA.

Keywords

Main Subjects

Minia Journal of Medical Research

Articles in Press, Accepted Manuscript
Available Online from 12 December 2023

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