Study of Serum ferritin Level in case of Premature Rupture of Membrane: Cross Sectional Study

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Document Type : Original Article

Authors

1 Department of Obstetrics & Gynecology, Faculty of Medicine, Minia University, Egypt.

2 Department of Obstetrics & Gynecology, Faculty of Medicine, Minia University, Egypt.

Abstract

Background: Serum ferritin level and c_reactive protein act as an acute phase reactants may be elevated due to subacute genital tract infection leading to preterm premature rupture of membranes.

Aim and objectives: To investigate whether serum ferritin level and crp can be utilized as a predictor of premature membrane rupture and chorioaminitis . Research Design: a case control study.

Subjects and methods: case control research was performed in obstetrics and gynecology department, Minia university on 150 pregnant women with intact membrane for measuring the serum ferritin, CBC, CRP levels according to their age, parity, gestational age every 2 weeks (from 30 till 37 weeks)

Results: Ferritin in all the 3 assessments was significantly increased in CRP positive cases when compared with CRP negative cases. Regarding comparison between CRP +ve and -ve cases, Age and Hb level were significantly increased in CRP +ve cases when compared with CRP -ve cases. There was significant positive correlation among S. Ferritin & CRP.

Conclusion: The current research demonstrated that elevated serum ferritin and CRP levels are predictive of spontaneous preterm premature membrane rupture because they reflect an acute-phase response to subclinical infections. Preterm premature rupture of membranes was associated with substantially elevated serum ferritin levels, estimated by three distinct assessments.

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Minia Journal of Medical Research

Articles in Press, Accepted Manuscript
Available Online from 13 November 2023

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