R( R)Lipopolysaccharide-induced acute lung injury in experimental male albino rats.

Document Type : Original Article

Authors

1 Physiology department. Faculty of Medicine. Minia University. Minia

2 physiology department, faculty of medicine, Minia university

3 Physiology Department,Minia University-Faculty of Medicine ,Minia University

4 Phsiology Department,Minia university-faculty of medicine,Minia university

Abstract

Acute lung injury (ALI) is a life-threatening lung disorder marked by rapid development of hypoxemia, severe dyspnea, tachypnea, widespread pulmonary interstitial edema, and alveolar edema, ultimately leading to respiratory failure and death. ALI can be induced both directly and indirectly. Lipopolysaccride (LPS) is the main cause of the toxicity linked to gram-negative bacteria and is frequently used to establish ALI models. Purpose of the study; this study was assigned to investigate the short-term LPS-induced lung injury. Basic procedures; rats were randomly assigned into 2 equal groups: Control group: where rats were allowed to run about in their cages with unrestricted access to food and water, Lipopolysaccharide (LPS) treated group: in which rats were received single intra-tracheal dose of LPS 3mg/kg on the 8th day after the beginning of the experimental study then sacrificed 24 hours after intra-tracheal LPS injection. Main findings; Intra-tracheal administration of LPS produced a significant elevation of plasma level of Ferritin as well as resulted in elevation of the level of pulmonary malondialdehyde (MDA) and tumor necrosis factor alpha (TNF-α) as compared to control group.

Principle conclusion: LPS was proved to produce extensive lung tissue damage as proved in the present study by inflammatory and oxidative markers. So, LPS can be considered as one model of lung injury.

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Minia Journal of Medical Research

Articles in Press, Accepted Manuscript
Available Online from 25 October 2023

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