(R) Prevalence of Neurological Manifestations in Egyptian Female Patients on Hemodialysis

Rabie, Marwa Mohamed; Hamdy, Mona; Okaily, Nagwa Ismail; Ahmed, Shimaa Salah

doi:10.21608/mjmr.2023.230159.1508

(R) Prevalence of Neurological Manifestations in Egyptian Female Patients on Hemodialysis

Document Type : Original Article

Authors

¹ Rheumatology and rehabilitation, faculty of medicine, minia university minia, egypt

² Department of Rheumatology, El-Minia faculty of medicine

³ faculty of medicine minia universty

⁴ Rheumatology and rehabilitation department, faculty of medicine, minia university minia, egypt

10.21608/mjmr.2023.230159.1508

Abstract

Background: End-stage renal disease (ESRD) is a significant problem in nearly all countries, and the prevalence has increased in developing countries . Normal kidneys filter and remove excess small proteins from the blood but in patients on dialysis, beta 2-microglobulin builds up in the blood. And may join together forming a few large molecules which can form deposits and eventually damage the surrounding tissues. This condition is called dialysis-related amyloidosis (DRA) .

Methods: Thirty eight female patients with CRF and on hemodialysis were enrolled to the study, their ages ranged from 27 to 70 years old. All patients were subjected to complete history taking and both general and local examination to detect any neurological affection. Patients with chronic diseases which can cause neurological manifestations, and patients with history of significant hand trauma were excluded from the study.

Results: Regarding to causes of hemodialysis, hypertension was the most common cause of hemodialysis in our patients(52.6%)of cases, followed by NSAIDs (21.1%) of cases, chronic obstructive uropathy was found in (7.9%)of cases also chronic glomerulonephritis was a cause in (7.9%)of cases and polycystic kidney was a cause in (10.5%) of cases. Regarding to diabetic patients, they were excluded from our study Patients complained of hand weakness more frequently than paresthesia and night awakening. And by clinical examination, sensory loss was more frequent than thenar wasting, hypoesthesia, also positive phalen and tinnel signs were common in our patients.

Conclusion: neurological manifestations including Carpal tunnel syndrome (CTS) are common in female patients on hemodialysis.

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