Neuroglobin as a biomarker in children with autism spectrum disorder.

Mohamed, Aya Ahmed; Mounir, Samir Mohammed; Saedii, Ahmed Abdelfadil; Fadle, Yossra Samir

doi:10.21608/mjmr.2023.219755.1452

Neuroglobin as a biomarker in children with autism spectrum disorder.

Articles in Press

Document Type : Original Article

Authors

¹ Resident at pediatric and neonatology department, faculty of Medicine, Minia University, Egypt

² Assistant Professor of pediatrics, Faculty of Medicine, Minia University, Egypt

³ Assistant Professor of clinical pathology Faculty of Medicine, Minia University, Egypt

⁴ Lecturer of pediatrics, Faculty of Medicine, Minia University, Egypt

10.21608/mjmr.2023.219755.1452

Abstract

Neuroglobin as a biomarker in children with autism spectrum disorder.

Abstract:

Background: Autism spectrum disorder (ASD) is a group of neurodevelopmental conditions diagnosed based on behavioral assessments that reveal deficits in social interactions.

Objectives:

The aim of this study is to investigate the possible role of neuroglobin as a biomarker in children with ASD.

Methods: This cross-sectional study was carried out at Minia University of Children, Obstetrics and Gynecology Hospital over the period from January 2022 to January 2023.

It was conducted on 19 children diagnosed with ASD attending to the Pediatric neuropsychiatry out-patient clinic or admitted to the pediatric neurology inpatient ward of Minia University of Children, Obstetrics and Gynecology Hospital during the period of the study.

They were subdivided into two groups:

Group I (N=19): included autistic children (14 males & 5 females) for fulfillment the criteria of autism.

Group II (N=30): included apparently healthy children (21 females & 9 males) whose age and sex were matched with group I.

The two groups were subjected to careful detailed history taking,

complete clinical examination, and laboratory investigations including:

complete blood count, Serum Neuroglobin level.

Results:

Our results show that there were statistically significant differences as regard serum neuroglobin level between group (I), group (II).

Conclusion:

In conclusion, higher serum neuroglobin levels among children with ASD than controls.

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Main Subjects