Assessment of serum VEGF level in children type 1 diabetes mellitus

Document Type : Original Article

Authors

1 pediatrics and neonatology department, faculty of medicine, minia university, Al minia, egypt

2 pediatric and neonatology department , faculty of medicine , minia university

3 faculty of medicine minia university clinical pathology department

4 Assistant professor of pediatrics, faculty of medicine Minia University

Abstract

Abstract

Background: Diabetes mellitus is a chronic metabolic disorder that affects numerous body organs and causes a variety of consequences. It is characterized by persistent hyperglycemia brought on by a problem with insulin production or by insulin resistance.

Aims: The aim of this study is to assess the level of serum VEGF (Vascular endothelial growth factor) in children with type 1 DM and its correlation with glycemic control.



Patient and Methods: This case-control study, was conducted on 50 children with type 1 DM (Group I) who had regular follow up in the Pediatric Endocrinology Outpatient Clinic. And controls are 20 other apparently healthy children (group II) with matched age and sex. Age: between 5 and 18 years, Duration of diabetes mellitus more than 3 years, normal A\C ratio, and normal fundus examination were included in our study. HBA1c and VEGF were done on all of the patients.

Results: our results show that there is a significant positive correlation between the duration of the disease, HBA1C (P value= 0.001), duration of disease and VEGF level (p value= 0.001), HBA1C level and VEGF serum level (p value= 0,001)

Conclusions: we demonstrated the significant correlation of VEGF and HbA1c and that should be done to all diabetic patients.

Key words;:diabetes mellitus, HBA1C, VEGF.

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Minia Journal of Medical Research

Articles in Press, Accepted Manuscript
Available Online from 25 July 2023

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