Role of 3D gradient echo MRI sequence in early detection of hemosiderin in hemophilic joint

Mahmoud, Doaa Abdelhakim; Amin, Mohamemed; Lotfy, Gehan; Issa, Ahmed

doi:10.21608/mjmr.2023.215326.1409

Role of 3D gradient echo MRI sequence in early detection of hemosiderin in hemophilic joint

Document Type : Original Article

Authors

¹ faculty of medicine , minia university , department of diagnostic radiology .Egypt

² Professor of diagnostic radiology, Faculty of medicine Minia university, Egypt

³ Professor of pediatric, Faculty of medicine Minia university, Egypt

⁴ lecturer of radiology .faculty of medicine, minia university , department of diagnostic radiology

10.21608/mjmr.2023.215326.1409

Abstract

Purpose of study: In hemophilic patients, Blood deposition within the joints is the cause of morbidity, this is because the affection of all joint components, this leads to inflammation and results in synovitis, osteochondral degeneration which leads to hemophilic arthropathy. 3D Gradient echo MRI sequences are available on most scanners including scanners with lower magnetic field strengths so they are commonly used in clinical practice. The purpose of this study is to investigate the role of T1 3D FFE MRI sequence which is one of gradient echo MRI sequences for assessment of hemosiderin deposition in the joints of hemophilic patients.

Methods: In this study we recruited 20 Hemophilic patients who admitted to hematology unit by attacks of bleeding or for follow up between august 2022 to April 2023. All patients underwent MRI for asymptomatic joint by conventional MRI sequences and T1 3D FFE sequence (It has the name of SPGR in GE machine and the name of FLASH in siemens machine ) correlation statical analysis was done between results of hemosiderin deposition by conventional sequences and by T1 3D FFE sequence.

Results: T13D FFE MRI sequence can detect early hemosiderin deposition in hemophilic joint better than other conventional sequences and there is no significant correlation between hemosiderin deposition by conventional sequences and by 3DT1FFE sequence.

Conclusion:3D T1 FFE is one of gradient MRI sequences has high capacity to detect even subtle intra-articular hemosiderin and provides a potential sensitive method for the early diagnosis and prognosis of hemophilic arthropathy.

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