Neutrophil CD64 expression in radiographic axial spondyloarthritis activity; is it valuable?

Document Type : Original Article

Authors

1 rheumatology, rehabilitation and physical medicine faculty of medicine Minia university Minia Egypt

2 rheumatology, rehabilitation and physical medicine faculty of medicine Minia university, El minia, Egypt

3 clinical pathology faculty of medicine Minia university El minia Egypt

Abstract

Background: In a number of inflammatory diseases, neutrophils that express CD64 may be utilized as a biomarker of inflammation.

This research examined individuals with radiographic axial spondyloarthritis (axial SPA) for neutrophil CD64 expression as a possible indicator of disease activity.

Methods: There were 32 patients with radiographic axial SPA who were matched for age and gender with 15 healthy controls. The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and neutrophil CD64 expression were evaluated. The patients with radiographic axial SPA were then separated into two groups based on their BASDAI scores: those with active disease (BASDAI> 4) and those with inactive disease (BASDAI< 4). Analysis was done on the expression of neutrophil CD64, ESR, CRP, and disease activity.

Results: Active radiographic axial SPA patients, inactive radiographic axial SPA patients, and controls did not significantly vary in neutrophil CD64 expression.

Between patients with active and inactive radiographic axial SPA, there is a statistically significant difference in ESR and CRP (P0.0001, 0.001, respectively).

Conclusion: neutrophil CD64 expression is not a useful diagnostic for assessing disease activity in radiographic axial SPA, which is a conclusion that can be drawn from the data.

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Minia Journal of Medical Research

Articles in Press, Accepted Manuscript
Available Online from 12 June 2023

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