Clinical Evaluation of Photobiomodulation Therapy on Regeneration of Necrotic Mature Permanent Teeth

Introduction: Regenerative endodontics was suggested as alternative treatment for necrotic mature permanent teeth to overcome the drawbacks of conventional treatment methods and showed better results when combined with photobiomodulation therapy (PBMT), so the aim of this study was to evaluate the clinical effect of photobiomodulation therapy on regeneration of necrotic mature permanent teeth.

Materials and Methods: 24 patients with age 9-13 were selected and randomly divided into two groups; control group (n=12), patients were treated with regenerative endodontics procedures (REPs) using blood clot scaffold, and study group (n=12), patients were treated with the same REPs as control group then treated with PBMT. In each group evaluation of pain, swelling, sinus tract, mobility, and cold sensibility test were performed

Results: Data analysis revealed that there was resolution of pain, swelling, and sinus tract in all cases during the follow up periods from the start to the end, no recurrence or pathological signs changes were detected clinically. Also, it revealed normal physiologic mobility of all subjects before and after revascularization procedures. For cold sensibility test, 6(60%) of cases in each group showed positive responses with no significant difference between both groups (p=1). There was a significant difference between values at different intervals in each group (p<0.001).

Conclusion: The results of this study showed that photobiomodulation therapy could accelerate the clinical success of regeneration of necrotic mature permanent teeth.