Effect of carbon tetra chloride (CCL4) on transforming growth factor -beta (TGF-β) expression in chronic liver disease.

Tammam, Omar Y.; Elrehany, Mahmoud A.; Abo-Aziza, Faten A.M.; Gaber, Shereen S.; Bayoumi, Asmaa M.A.

doi:10.21608/mjmr.2021.237749

Effect of carbon tetra chloride (CCL4) on transforming growth factor -beta (TGF-β) expression in chronic liver disease.

Document Type : Original Article

Authors

¹ Department of biochemistry, faculty of pharmacy, Deraya University, Minia, Egypt

² Department of biochemistry, faculty of pharmacy, Deraya University, Minia, Egypt ** Department of biochemistry, faculty of medicine, Minia University, Minia, Egypt

³ Department of Parasitology and Animal Diseases, Veterinary Research Division, National Research Center, Giza, Egypt.

⁴ Department of biochemistry, faculty of medicine, Minia University, Minia, Egypt

10.21608/mjmr.2021.237749

Abstract

Background: The liver is one of the most important organs in the human body because of its utmost importance, and it plays many essential roles for the body. Carbon tetrachloride affects the body in general and the liver, which sometimes leads to the occurrence of chronic hepatitis and may reach its climax and cause fibrosis. One of the effects of carbon tetrachloride is the stimulation of the beta-TGF pathway. Results: After CCL4 administration; There is highly statistically significant difference in expression level of TGF-β (p < 0.005). Conclusions: This study shows that carbon tetra chloride is promotor for several liver diseases that occur due to activation and upregulation of TGF-β.

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