Correlation between Serum Inflammatory and Oxidative Stress Markers with Blood Pressure in Preeclampsia

Document Type : Original Article

Authors

1 Department of Medical Physiology, Faculty of Medicine, Beni-Suef University, Egypt.

2 Department of Medical Physiology, Kasr Al-Aini Faculty of Medicine, Cairo University, Egypt.

Abstract

Objectives: To evaluate the serum pro-inflammatory cytokines (Tumor necrosis alpha (TNF α)), 
oxidative stress marker(Malondialdehyde(MDA)) and serum antioxidant biomarker (Superoxide 
dismutase(SOD)) and study their correlations with blood pressure (BP) in preeclampsia (PE).
Methods: Fifty pregnant women (18 - 35 years old) were divided into two groups each with 25 
pregnant women: preeclampsia group and control group. Results: Blood pressure, mean serum TNF 
α, and MDA were significantly higher, while, the mean serum value of SOD was significantly lower in 
the pregnant women with preeclampsia than in the control pregnant women. Also, there was a 
significant positive correlation between TNF α, MDA, and BP. Conclusion: Elevated both serum TNF 
α, MDA and decreased SOD are the possible mechanisms involved in the pathogenesis of PE.
Early detection of PE allows for planning of appropriate monitoring of PE and for prevention of 
complications.

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