Protective effect of p-coumaric acid on fructose induced- insulin resistance in albino rats

Document Type : Original Article

Authors

1 Department of Medical Physiology, Faculty of Medicine, Beni- Suef University, Egypt.

2 Department of Medical Physiology, Kasr Al-Aini Faculty of Medicine, Cairo University, Egypt

Abstract

Background: Treatment of diabetes mellitus (DM) without any side effects is still a challenge. This leads to increase the demand for natural products with antidiabetic activity with fewer side effects. P-Coumaric acid has several pharmacological and biological actions, such as antioxidant (radical scavenging), neuroprotective, cardioprotective besides its antidiabetic effect. So we aim to evaluate the protective effect of p-coumaric acid on fructose-induced insulin resistance in rats. Materials and Methods: Thirty male adult white albino rats were randomly divided into 3 groups of 10 animals each. control group received normal saline orally fructose group received fructose 60% dissolved in water for 5 weeks coumaric +fructose group received p-coumaric acid 100mg/kg/day for 4 weeks orally followed by fructose 60 ‰ dissolved in water for 5 week. At the end of the experimental period, BMI , blood pressure , insulin, glucose, lipid profile, ALT and AST were measured . Oxidative stress biomarkers were measured in liver tissue and HOMA-IR test was taken as an indicator of insulin resistance. Results There was significant elevation of BMI, blood pressure, fasting plasma glucose, fasting plasma insulin, HOMA-IR, fasting plasma (cholesterol, triglycerides and LDL levels) and MDA with decrease of HDL, SOD and glutathione in fructose group when compared to control group. Administration of p-coumaric acid prevents these results. Conclusion: treatment with p-coumaric acid protect against high fructose diet-induced hyperglycemia, insulin resistance, dyslipidemia and oxidative stress.

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