Immunohistochemical study of GATA3 and Androgen receptors in breast cancer

Document Type : Original Article

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Department of Pathology, El-Minia Faculty of Medicine

Abstract

Introduction: Breast carcinoma (BC) is a major global problem, with nearly 1.7 million new cases 
occurring among women worldwide each year (International Agency for Research on Cancer. 2016).
The aim of this work was to: Study the immunohistochemical expressions of GATA 3 binding 
protein (GATA3) and Androgen receptor (AR) in invasive duct carcinoma. Material and Methods: 
Tissue specimens: The present study comprised 61 formalin – fixed, parafin – embedded tissue 
specimen invasive duct breast carcinoma. They were randomly selected and retreived from the 
archives of histopathological laboratories of Minia oncology center, pathology department, in period 
between 2012 and 2016. Results: Clinicopathological features: The current study included 61 cases 
of invasive duct carcinoma (NST) of female breast. Data regarding different clinical and 
histopathological features for cases investigated in this study. Discussion: Breast cancer (BC) is one 
of the most frequent cancers worldwide and is considered the second leading cause of carcinoma 
related death (15%) after lung carcinoma (Baade, 2017). Summary: Breast carcinoma (BC) is a 
major global problem, with nearly 1.7 million new cases occurring among women worldwide each 
year. 

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Minia Journal of Medical Research
Volume 30, Issue 1
March 2019
Pages 233-235

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