Resistance to anti-angiogenic therapy in patients with neovascular age-related macular degeneration

Document Type : Original Article

Authors

Department of Ophthalmology, Minia University Hospital, Minia, Egypt

Abstract

Age-related macular degeneration (AMD) is the most common cause of irreversible vision loss in 
developed countries among individuals aged 50 years and older. The neovascular form of late AMD 
affects only 10% of patients but is responsible for most cases of severe vision loss due to the disease. 
Despite their good results in treatment of neovascular AMD, anti-angiogenic agents can be ineffective 
in a subset of patients considered resistant to therapy. Several mechanisms have been proposed to 
explain his phenomenon and, subsequently, different management strategies are currently under 
investigation to improve patient outcomes with anti-angiogenic therapy.

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Minia Journal of Medical Research
Volume 30, Issue 1
March 2019
Pages 212-216

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