Document Type : Original Article
Authors
1
Department of Rheumatology and Rehabilitation,
2
Department of clinical pathology, Faculty of Medicine, El-Minia University, Egypt.
3
*Department of Radiology***, Faculty of Medicine, El-Minia University, Egypt.
Abstract
Background: Osteoarthritis is a painful chronic joint disease characterized by structural
changes to the whole joint, including loss of articular cartilage, development of osteophytes,
synovial inflammation, subchondral bone changes, meniscal damage, muscle weakness, and
ligamentous laxity. Aim of the work: To detect osteopontine (OPN) in knee osteoarthritis.
Methods: 60 patients diagnosed as primary knee OA fulfilling Arthritis Rheum 1986 OA
classification criteria, And 60 healthy control were included. All patients subjected to
through history taking and full examination, body mass index, plain x ray knees PA view to
assess severity according to Kellgren and Laurence grading, plasma and synovial fluid OPN
levels, and plasma OPN for control. Assessment of pain for OA patients by patient pain visual
analogue scale (VAS) and for functional status by Western Ontario and McMaster
Universities Osteoarthritis Index (WOMAC), ESR,CRP were done. Results: there was
significant difference between both groups regarding plasma osteopontine (p<0.0001), OPN
levels in OA patients in plasma and synovial fluid was correlated with each other (p <0.0001),
patient pain VAS, WOMAC score, K-L grading were correlated with plasma OPN levels with
p value (0.001, <0.001, <0.001), and with synovial fluid OPN levels in primary OA patients
with p value (0.008, <0.001, <0.001) respectively. ESR positively correlated with plasma
OPN p=0.004. Conclusion: OPN is higher in OA patients more than control, and it is higher
in synovial fluid than plasma in knee OA patients, OPN correlated with markers of systemic
inflammation and has impact on functional status so it can be used as a diagnostic and
prognostic factor in knee osteoarthritis.
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