Serum Dickkopf-1 level in neonates with Hypoxic-Ischemic Encephalopathy

Afifi, Mohamed F.; Aboul-Fotoh, Laila E.; Ahmed, Mostafa A. El-Sayed; Hassan, Mona M.

doi:10.21608/mjmr.2022.222769

Serum Dickkopf-1 level in neonates with Hypoxic-Ischemic Encephalopathy

Document Type : Original Article

Authors

¹ Department of Pediatrics, Minia University, Minia, Egypt

² Department of Clinical Pathology, Minia University, Minia, Egypt

³ Department of Clinical Pathology, Minia health insurance hospital, Minia, Egypt

10.21608/mjmr.2022.222769

Abstract

Objective: To measure the serum Dickkopf-1 level in neonates with HIE and to study its
relation to the neurodevelopmental outcome in those neonates in comparison to healthy neonates.
Methods: We measured serum levels of Dkk-1 by ELISA in neonates with HIE (n = 40) and in
healthy controls (n = 30). Results: Dkk-1 serum levels increased significantly in HIE neonates than in
healthy control, Serum DKK-1 levels increased significantly in severe HIE patients. Conclusion:
DKK1 level was higher in neonates with HIE than normal neonates and DKK1 level correlated
positively with the degree of HIE.

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