Background: Liver cancer, predominantly hepatocellular carcinoma (HCC), is the second most deadly cancer worldwide. HCC is the most rapidly increasing cause of cancer-related mortality in the U.S. In Canada, total health care costs associated with HCV are expected to increase by 60% until they peak in 2032. Given the extremely frequent tumour recurrence even after aggressive treatment (70% after 5 years of surgical resection) and limited treatment options available for advanced-stage liver disease, including liver transplantation, a costly proposition, prevention of HCC development in patients with advanced liver fibrosis may be the most effective strategy to substantially impact patient survival. Aim of study: to detect the level of miR224 in different stages of hepatocellular carcinoma. Methods: An observational study, in Tropical Medicine Department, El-Minia University Hospital, ElMinia,-Egypt. Patients with hepatocellular carcinoma on top of HCV induced Liver cirrhosis collected among the patients of tropical medicine department from January 2017 to January 2018. Patients were divided into 3 groups according to Barcelona classification of liver cancer (BCLC) into, group 1 with BCLC A, group 2 with BCLC B, group C with BCLC C, and control group of LC without HCC, for all groups: history, examination and routine investigations, abdominal ultrasound, Multislice CT scan and miR-224 assay were done. Results: there was a significant difference between the level of miR 224 in different stages of hepatocellular carcinoma with the lowest level in BCLC A and the highest level in BCLC C with P value 0.001 indicating its role in predicting aggressiveness of hepatocellular carcinoma. Conclusion: miR-224 could serve as a good prognostic biomarker for HCC, and can be used as a marker predicting aggressiveness of HCC.
Semeda, N., Mohammed, H., Saad, Z., & Soliman, W. (2019). Detection of the level of micro RNA 224 in patients with hepatocellular carcinoma.. Minia Journal of Medical Research, 30(3), 242-245. doi: 10.21608/mjmr.2022.221954
MLA
Nady M. Semeda; Hala I. Mohammed; Zeinab M. Saad; Wael Soliman. "Detection of the level of micro RNA 224 in patients with hepatocellular carcinoma.". Minia Journal of Medical Research, 30, 3, 2019, 242-245. doi: 10.21608/mjmr.2022.221954
HARVARD
Semeda, N., Mohammed, H., Saad, Z., Soliman, W. (2019). 'Detection of the level of micro RNA 224 in patients with hepatocellular carcinoma.', Minia Journal of Medical Research, 30(3), pp. 242-245. doi: 10.21608/mjmr.2022.221954
VANCOUVER
Semeda, N., Mohammed, H., Saad, Z., Soliman, W. Detection of the level of micro RNA 224 in patients with hepatocellular carcinoma.. Minia Journal of Medical Research, 2019; 30(3): 242-245. doi: 10.21608/mjmr.2022.221954
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