Introduction: Preeclampsia is a clinical syndrome defined as the new onset of hypertension and proteinuria during the second half of pregnancy. Aim of the work: The main target of the current research is: to exploit the GABA mimetic and potentiating effect of intrathecal midazolam to ameliorate the glutamate mediated preecmlapsia induced neuronal excitotoxicity and cerebro-vasculer vasospasm assessed by blood flow vascular indices (pulsitility index, resistive index and mean flow velocity) in maternal MCA in case of sever preeclampsia. Patients and methods: The current study was planned to be double blind placebo controlled single center randomized prospective study in which 100 parturient ASA IIe with severe preeclampsia were recruited into 2 groups 50 ladies in each group scheduled for emergency C.S after obtaining approval of the local ethics committee of Faculty of Medicine, El-Minia University and informed written consent from parturients husband or next of kin. Study was carried out from December 2017 to August 2018. Results: This prospective randomized double blind study included 100 parturient allocated in 2 groups, 50 cases in each. All studied groups received lumbar subarachnoid block by bupivacaine 0.5%12.5 mg + 1 mg midazolam in (M) group or 0.2 cm sterile saline 0.9% Nacl in (C) group. Recommendations: We recommend: Future studies on midazolam impact over maternal MCA resistive indices should examine different. 1- Using intrathecal midazolam in the dose of 1 mg in cases of severe preeclampsia as an adjuvant to bupivacaine 0.5% in the dose of 12.5 mg. 2- Increasing frequency of TCD readings to be at the base, 6h, 12h, 18h & 24hs to be more accurate. 3- Using TCD antenatal in the future studies to early pick up ladies that may develop preeclampsia.
Mickhael, H., Amine, M., Raouf, M., & Mohamed, S. (2019). Effect of Adding Midazolam to Bupivacaine 0.5% in Spinal Anesthesia on Middle Cerebral Artery Blood Flow in Patients with Pre-eclampsia. Minia Journal of Medical Research, 30(3), 191-194. doi: 10.21608/mjmr.2022.221925
MLA
Hany K. Mickhael; Mohamed A. Amine; Mina M. Raouf; Samar M. Magdy Mohamed. "Effect of Adding Midazolam to Bupivacaine 0.5% in Spinal Anesthesia on Middle Cerebral Artery Blood Flow in Patients with Pre-eclampsia". Minia Journal of Medical Research, 30, 3, 2019, 191-194. doi: 10.21608/mjmr.2022.221925
HARVARD
Mickhael, H., Amine, M., Raouf, M., Mohamed, S. (2019). 'Effect of Adding Midazolam to Bupivacaine 0.5% in Spinal Anesthesia on Middle Cerebral Artery Blood Flow in Patients with Pre-eclampsia', Minia Journal of Medical Research, 30(3), pp. 191-194. doi: 10.21608/mjmr.2022.221925
VANCOUVER
Mickhael, H., Amine, M., Raouf, M., Mohamed, S. Effect of Adding Midazolam to Bupivacaine 0.5% in Spinal Anesthesia on Middle Cerebral Artery Blood Flow in Patients with Pre-eclampsia. Minia Journal of Medical Research, 2019; 30(3): 191-194. doi: 10.21608/mjmr.2022.221925
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