Resistin as an inflammatory marker in Lupus Nephritis

Document Type : Original Article

Authors

1 Department of Rheumatology and Rehabilitation, Faculty of Medicine, El-Minia University,

2 Department of Clinical Pathology, Faculty of Medicine, El-Minia University, Egypt.

Abstract

Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that 
predominately affects women. It is characterized by a broad spectrum of clinical manifestations. 
Adipokines are a diverse family of soluble mediators with a range of specific actions on the immune 
response. Among the various adipokines is Resistin. Methods: 26 patients with lupus nephritis with 
age ranged between 18-48 years and 20 healthy age, sex and BMI matched individuals were enrolled 
in this study. Full history, clinical examination and laboratory investigations were performed for all 
patients including serum resistin level. Results: The level of serum resistin was higher in the patients 
than the controls (p < 0.001). Also, Serum resistin level correlated positively with the levels of ESR 
(p< 0.001), CRP (p= 0.008). Serum resistin levels correlated negatively with levels of C3 (p< 0.001) 
and C4 (p< 0.001). Conclusion: Serum resisitin level can be used as a marker of inflammation in
patients with lupus nephritis.

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