Sarcopenia in Chronic Liver Diseases

Document Type : Original Article

Authors

1 Department of Internal Medicine, Faculty of Medicine, Minia University, P O:61111

2 Department of Radiology, faculty of Medicine, Minia University, PO: 61111

3 Department of Internal Medicine, Faculty of Medicine, Minia University, P O:61111.

Abstract

Background: Sarcopenia is defined as a muscle mass two standard deviations below the 
healthy young adult mean, and although it is associated with aging, it can also be present as a 
result of chronic diseases and malignancy, and it ultimately leads to decreased functional 
capacity and higher risk of morbidity and mortality in different groups of patients. Aim of 
The work: The aim of this study is to investigate the frequency of sarcopenia in HCV 
induced chronic liver diseases. Subjects and Methods: This case control hospital based study 
recruited patients with HCV-induced chronic liver disease of different functional grades 
according to Child-Pough and Meld scores and a group of healthy subjects as controls. All 
participants were assessed for demographic, hematological, and biochemical liver and renal 
profiles. Radiological diagnostic parameters of sarcopenia were determined by subjecting all 
participants to MDCT abdominal scan at the level of psoas muscle. Results: Using computed 
tomography measurement of psoas muscle thickness/height as a diagnostic validated test for 
sarcopenia, sarcopenia was detected in 52.5% of our liver cirrhosis patients. Conclusion and 
future recommendations In conclusion, sarcopenia is a common complication of cirrhosis 
and adversely affects survival, quality of life, and response to stress including infection and 
surgery.

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