Evaluation of early progesterone use in high-risk women to prevent pre-term birth (PTB) predicted with a high level of Cervico-Vaginal Fluid (CVF) trappin2/elafin protein

Document Type : Original Article

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Department of Obstetrics and Gynecology, El-Minia Faculty of Medicine

Abstract

Introduction: Preterm birth is a global healthcare problem associated with significant neonatal 
morbidity and mortality and substantial healthcare costs. Aim of the work: Evaluate the role of early 
use of micronised vaginal progesterone at 14 weeks gestation in high risk women for SPTB predicted 
with high level of trappin2/elaffin protein in Cervico-Vaginal Fluid (CVF). Patients and Methods: 
This is a prospective study included 50 women who are 13 weeks of gestation and had high risk for 
preterm birth attend to obstetric clinic of Minia university hospital and Abo Korkas hospital during 
the period from November 2015 to December 2016. The study was approved by the faculty of 
medicine, Minia university ethical committee. Results: A total of 50 women who are 13 weeks of 
gestation and had high risk for preterm were included in this study. The results were presented as 
descriptive and analytical statistics and presented in tables. Conclusion: From the obtained results, it 
could be concluded that: To the best of our knowledge, very few work was done to study the relation 
between trappin2/elaffin protein cervical shortening and prediction of spontaneous preterm birth, so 
very little data is available about this topic.

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