Impact of Mono-therapy Antiepileptic Drugs on lipid profile of epileptic children

Document Type : Original Article

Authors

1 Department of Neurology, El-Minia university Egypt

2 Department of Pediatric, El-Minia university Egypt

Abstract

Background: Epilepsy is one of the most common neurological disorders, which required 
long term therapy or lifelong treatment in some cases. Chronic use of antiepileptic 
drugs (AEDs) therapy might modify some vascular risk factors, Since atherosclerotic 
vascular alterations may start early in life, this study focuses on dyslipidemia which is a major 
atherogenic risk factor among epileptic children. The aim of this study: to evaluate different 
effects of mono-therapy antiepileptic drugs (AEDs) on lipid profile of children with 
idiopathic epilepsy. Methods: this study was carried out on 80 children , their age rage (7-
16) divided into group I included 20 healthy children their age and sex matched served as a 
control ,group II included 20 newly diagnosed epileptic children ( according to ILAE2014
diagnostic criteria of epilepsy ) they didn't receive medication till the time of study and and 
lastly group III included epileptic children receiving monotherapy AEDs n=40 ,where the 
duration of treatment were not less than 2 months ; groupIII divided into four subgroup 
according to the type of AEDs . Measurement received for all participant include detailed 
history, clinical examination ,neurological examination and serum fasting lipid profile, while 
the analysis of seizure (onset ,type, frequency and classification of epilepsy according to 
(ILAE2017)) , inter-ictal EEG ,history of AEDs administration; daily dose and compliance to 
medication were for epileptic patient only. Result: serum TC, LDL were significantly higher 
in epileptic children receiving AEDs than control groups or group of newly diagnosed 
epileptic children , TG and VLDL were higher in epileptic children treated with old AEDs 
than other groups ,while newly diagnosed epileptic children have higher LDL than control 
group, on the other hand there is a significant higher HDL in epileptic children treated with 
new antiepileptic drugs than newly diagnosed epileptic children and epileptic children treated 
with old antiepileptic drugs. Conclusion: epilepsy and antiepileptic drugs especially old 
generation antiepileptic drugs are considered risk factors of dyslipidemias& atherosclerosis.
We recommend routine monitoring of the serum lipid profile in epileptic children especially 
they treated with old generation AEDs (VAP and CBZ namely). 
 

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