Immune mediated thrombocytopenia (ITP) is an autoimmune bleeding disorder characterized by production of auto-antibodies against platelet antigens. It is obvious that regulatory T cells (Tregs) have a major role in controlling immune homeostasis and preventing autoimmunity. To investigate the frequency of Tregs, twenty newly diagnosed, twenty chronic ITP children and twenty age and sex matched healthy controls were recruited. The peripheral blood mononuclear cells were isolated and the proportion of Tregs was defined by flow cytometry method. Results showed that the frequency of Tregs significantly decreased in newly diagnosed and chronic ITP patients compared to those in healthy controls. It could be concluded that Tregs might play a role in the pathogenesis of ITP.
Matta, S., Salah, K., & Abd El-Naeem, E. (2019). Possible Role of Regulatory T Cells (CD4+and CD25+) in Pathogenesis of Childhood Immune Mediated Thrombocytopenia. Minia Journal of Medical Research, 30(4), 152-154. doi: 10.21608/mjmr.2022.221702
MLA
Sally F. Matta; Khaled M. Salah; Emad A. Abd El-Naeem. "Possible Role of Regulatory T Cells (CD4+and CD25+) in Pathogenesis of Childhood Immune Mediated Thrombocytopenia", Minia Journal of Medical Research, 30, 4, 2019, 152-154. doi: 10.21608/mjmr.2022.221702
HARVARD
Matta, S., Salah, K., Abd El-Naeem, E. (2019). 'Possible Role of Regulatory T Cells (CD4+and CD25+) in Pathogenesis of Childhood Immune Mediated Thrombocytopenia', Minia Journal of Medical Research, 30(4), pp. 152-154. doi: 10.21608/mjmr.2022.221702
VANCOUVER
Matta, S., Salah, K., Abd El-Naeem, E. Possible Role of Regulatory T Cells (CD4+and CD25+) in Pathogenesis of Childhood Immune Mediated Thrombocytopenia. Minia Journal of Medical Research, 2019; 30(4): 152-154. doi: 10.21608/mjmr.2022.221702
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