Background: Lower respiratory tract infections (LRTI) account for a considerable proportion of morbidity and antibiotic use. We aimed to identify the causative bacteria, antibiotic sensitivity and resistance of hospitalized adult patients due to LRTI in Upper Egypt. Methods: A multicentre prospective study was performed at Minia University Hospitals for 3 years. Samples included sputum or bronchoalveolar lavage (BAL) for staining and culture, and serum for serology. Samples were cultured on 3 bacteriological media (Nutrient, Chocolate, MacConkey's agars). Colonies were identified via MicroScan WalkAway-96. Pneumoslide IgM kit was used for detection of atypical pathogens via indirect immunofluorescent assay. Results: The predominant isolates in 360 patients with CAP were S. pneumoniae (36%), C. pneumoniae (18%), and M. pneumoniae (12%). A higher sensitivity was recorded for moxifloxacin, levofloxacin, macrolides, and cefepime. A higher of resistance was recorded for doxycycline, cephalosporins, and β-lactam-β-lactamase inhibitors. The predominant isolates in 318 patients with HAP were, methicillin-resistant Staphylococcus aureus; MRSA (23%), K. pneumoniae (14%), and polymicrobial in 12%. A higher sensitivity was recorded for vancomycin, ciprofloxacin, and moxifloxacin. Very high resistance was recorded for β-lactam-βlactamase inhibitors and cephalosporins. The predominant organisms in 376 patients with acute exacerbation of chronic obstructive pulmonary diseases (AECOPD) were H. influnzae (30%), S. pneumoniae (25%), and M. catarrhalis (18%). A higher sensitivity was recorded for moxifloxacin, macrolides and cefepime. A higher rate of resistance was recorded for aminoglycosides and cephalosporins. Conclusions: The most predominant bacteria for CAP in Upper Egypt are S. pneumoniae and atypical organisms, while that for HAP are MRSA and Gram negative bacteria.
Omran, A., Saedii, A., Roushdy, A. S., Mohamed, A., & El-Hakeem, M. (2019). Bacterial causes of lower respiratory tract infections in hospitalized patients in upper Egypt.. Minia Journal of Medical Research, 30(4), 121-128. doi: 10.21608/mjmr.2022.221698
MLA
Ahmad A. Samie Omran; Ahmed A. Saedii; Al Shimaa I. Roushdy; Ayat M. Mohamed; Mohammed A. El-Hakeem. "Bacterial causes of lower respiratory tract infections in hospitalized patients in upper Egypt.", Minia Journal of Medical Research, 30, 4, 2019, 121-128. doi: 10.21608/mjmr.2022.221698
HARVARD
Omran, A., Saedii, A., Roushdy, A. S., Mohamed, A., El-Hakeem, M. (2019). 'Bacterial causes of lower respiratory tract infections in hospitalized patients in upper Egypt.', Minia Journal of Medical Research, 30(4), pp. 121-128. doi: 10.21608/mjmr.2022.221698
VANCOUVER
Omran, A., Saedii, A., Roushdy, A. S., Mohamed, A., El-Hakeem, M. Bacterial causes of lower respiratory tract infections in hospitalized patients in upper Egypt.. Minia Journal of Medical Research, 2019; 30(4): 121-128. doi: 10.21608/mjmr.2022.221698
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