Purpose: To compare no-sedation versus daily interruption of sedation (DIS) in COPD patients receiving mechanical ventilation upon the ventilator-free days. Martials and methods: Patients were randomly assigned to either DIS (n=50) or no-sedation (n=47) (intervention group). Patients failed to be managed by no-sedation strategy (n=9, 19.1%) were shifted to DIS, but analyzed in their parent group (intention to treat principle). Ventilator-free days was the primary outcome measure. Secondary outcome measures included: length of stay in the hospital and in intensive care unit (ICU), the incidence of ventilator-associated pneumonia (VAP), and weaning process (simple, difficult or prolonged). Nurse workload was assessed by the visual analogue scale (VAS). Results: no significant difference was found in ventilator-free days between DIS and no-sedation (mean 19.9 vs. 21.5 days, P=0.6). As well, we found no significant difference in length of ICU stay (P=0.7) and hospital stay (P=0.4). There was no significant difference in the incidence of VAP (P=1.0) nor in the weaning process (simple, difficult or prolonged) (P=0.328) between the two groups. The no-sedation group showed a higher nurse workload in comparison to the DIS group. (4.38 vs. 5.69, P<0.001). Conclusions: No-sedation protocol can be used safely in COPD patients with respiratory failure, but with no influence upon the ventilator-free days.
Abdelghany, M., Alkarn, ,. A., Khalaf, M., Gadalla, W., & Kamel, E. (2020). No-Sedation in Mechanically Ventilated Chronic Obstructive Pulmonary Disease Patients; A Randomized Controlled Trial.. Minia Journal of Medical Research, 31(1), 12-21. doi: 10.21608/mjmr.2022.221383
MLA
Mohamed F. Abdelghany; , Atef F. Alkarn; Mohammad G.A. Khalaf; Wafaa A.H. Gadalla; Emad Z. Kamel. "No-Sedation in Mechanically Ventilated Chronic Obstructive Pulmonary Disease Patients; A Randomized Controlled Trial.". Minia Journal of Medical Research, 31, 1, 2020, 12-21. doi: 10.21608/mjmr.2022.221383
HARVARD
Abdelghany, M., Alkarn, ,. A., Khalaf, M., Gadalla, W., Kamel, E. (2020). 'No-Sedation in Mechanically Ventilated Chronic Obstructive Pulmonary Disease Patients; A Randomized Controlled Trial.', Minia Journal of Medical Research, 31(1), pp. 12-21. doi: 10.21608/mjmr.2022.221383
VANCOUVER
Abdelghany, M., Alkarn, ,. A., Khalaf, M., Gadalla, W., Kamel, E. No-Sedation in Mechanically Ventilated Chronic Obstructive Pulmonary Disease Patients; A Randomized Controlled Trial.. Minia Journal of Medical Research, 2020; 31(1): 12-21. doi: 10.21608/mjmr.2022.221383