Leptin Receptor Expression in Obesity-Associated Acanthosis Nigricans

Document Type : Original Article

Authors

1 Department of Dermatology , Andrology , STDS Al-Azhar university (Assiut), Egypt.

2 Department of Pathology Al-Azhar university (Assiut), Egypt.

3 Department of Dermatology ,Andrology And STDS At Dairout Hospital, Assiut, Egypt.

Abstract

Background: Obesity-associated acanthosis nigricans is the most common type of acanthosis 
nigricans. Aim of wok: To detect leptin receptor expression in the skin lesion affected by obesityassociated acanthosis nigricans. Patients and methods: Twenty patients suffering from obesityassociated acanthosis nigricans were included in this prospective study. Complete history taking, 
thorough general examination and calculation of body mass index were done for all patients. Leptin 
receptor expression was investigated in skin lesion and perilesional skin by immunohistochemistry.
Results: The mean age of the patients was 19.5 ±7.561 years and the mean duration of the disease 
was 8.6 ± 6.44 years. 14 patients were females and 6 patients were males. The mean BMI of the 
examined patients was (31.5 ± 4.4). The expression of leptin receptors was significantly higher in 
skin lesions than perilesional skin of the patients. 
Conclusion: leptin receptor expression was significantly higher in skin lesions affected by obesityassociated AN. 

Keywords

Main Subjects

Minia Journal of Medical Research
Volume 31, Issue 2
April 2020
Pages 308-312

Files

Share

How to cite

Statistics