Background: Vitiligo is a common acquired immune disorder of the skin characterized by the presence of milky white depigmented macules in various distributions. It is an autoimmune disorder caused by the destruction of melanocytes in the skin. Its immunopathogenesis is not fully understood, but there are inflammatory alterations in the skin microenvironment. Aim of the work: This study aims to estimate the level of IL-33 and TNF–alpha in lesional tissues of patients with vitiligo in comparison with healthy controls. Subjects and methods: this is a case control study that was conducted on outpatients attending Beni-Suef University Hospital, 30 patients with vitiligo and 30 healthy controls, Tissue samples was be collected by punch biopsy (4mm) in diameter from Lesion (vitiliginous areas) of the patients and normal skin from the healthy controls. Results: TNF-α and IL-33 tissue levels were significantly increaesd in patients with vitiligo compared with healthy controls. No correlation between Level of Interlukien-33 and level of Tumor Necrosis Factor-α in Vitiligo Lesions among Studied Cases; (p-values> 0.05). Conclusion: Tissue IL-33 levels in patients with vitiligo were significantly increased compared with healthy controls. IL-33 could be considered a reliable marker for the disease. These results also might partly explain the mechanism for TNF-α inhibitor efficacy in patients with vitiligo. Tumour necrosis factor (TNF)‐α, a proinflammatory cytokine central to many autoimmune diseases, has been implicated in the depigmentation process in vitiligo, as it is also increased in patients with vitiligo compared with healthy controls.
El-Rifaie, A., Rashed, L., Abd Allah, A., & El-Ashry, E. (2020). Estimation of the Level of Interlukien-33 and Tumour Necrosis Factor-α in Lesional Tissues of Patients with Vitiligo. Minia Journal of Medical Research, 31(2), 293-302. doi: 10.21608/mjmr.2022.221077
MLA
Abd E. El-Rifaie; Laila A. Rashed; Ahlam H. Abd Allah; El-Shaimaa S. A. El-Ashry. "Estimation of the Level of Interlukien-33 and Tumour Necrosis Factor-α in Lesional Tissues of Patients with Vitiligo". Minia Journal of Medical Research, 31, 2, 2020, 293-302. doi: 10.21608/mjmr.2022.221077
HARVARD
El-Rifaie, A., Rashed, L., Abd Allah, A., El-Ashry, E. (2020). 'Estimation of the Level of Interlukien-33 and Tumour Necrosis Factor-α in Lesional Tissues of Patients with Vitiligo', Minia Journal of Medical Research, 31(2), pp. 293-302. doi: 10.21608/mjmr.2022.221077
VANCOUVER
El-Rifaie, A., Rashed, L., Abd Allah, A., El-Ashry, E. Estimation of the Level of Interlukien-33 and Tumour Necrosis Factor-α in Lesional Tissues of Patients with Vitiligo. Minia Journal of Medical Research, 2020; 31(2): 293-302. doi: 10.21608/mjmr.2022.221077
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