Background: Colorectal cancer is one of the most common cancers worldwide. It is the result of a complex genetic mutations and environmental factors. TWIST1 is expressed in a wide range of normal and neoplastic tissues and has emerged as an important regulator of diverse functions critical in cancer biology including cellular transition, proliferation, metastasis and gene expression. Methods: Immunohistochemical staining of TWIST1 was conducted on 50 tissue specimens of colorectal adenocarcinoma by using the avidin biotin-peroxidase complex method with diaminobenizidine chromagen detection system. Results: High TWIST1 expression was detected in 62% of cases. TWIST1 expression showed statistically significant correlation with lymph node metastasis (p= 0.007) and advanced tumor stage assessed by modified Dukes staging (p = 0.043). Conclusions: TWIST1 expression is significantly associated with poor prognostic factors and thus can be used as a prognostic indicator for colorectal carcinoma patients.
Tawfik, H., Kamel, M., El-Hussieny, M., & Thabet, D. (2020). Immunohistochemical Expression of TWIST1 in Colorectal Adenocarcinoma. Minia Journal of Medical Research, 31(2), 257-260. doi: 10.21608/mjmr.2022.221057
MLA
Heba M. Tawfik; Mariana F. Kamel; Maram El-Hussieny; Dalia M. Thabet. "Immunohistochemical Expression of TWIST1 in Colorectal Adenocarcinoma". Minia Journal of Medical Research, 31, 2, 2020, 257-260. doi: 10.21608/mjmr.2022.221057
HARVARD
Tawfik, H., Kamel, M., El-Hussieny, M., Thabet, D. (2020). 'Immunohistochemical Expression of TWIST1 in Colorectal Adenocarcinoma', Minia Journal of Medical Research, 31(2), pp. 257-260. doi: 10.21608/mjmr.2022.221057
VANCOUVER
Tawfik, H., Kamel, M., El-Hussieny, M., Thabet, D. Immunohistochemical Expression of TWIST1 in Colorectal Adenocarcinoma. Minia Journal of Medical Research, 2020; 31(2): 257-260. doi: 10.21608/mjmr.2022.221057
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