Sitagliptin one of the anti-diabetic drugs. We aimed to evaluate the gastroprotective effect of sitagliptin in indomethacin-induced peptic ulcer in rats. Adult male albino rats were divided to four groups; control, sitagliptin (SIT), indomethacin (IND) and IND+SIT group. In each group, ulcer index, gastric mucosal malondialdehyde (MDA), total nitrites (NOx) and Tumor necrosis factoralpha (TNF-α) were determined. In IND+SIT group, ulcer index, MDA and TNF-α were reduced, as compared to IND group. At the same time, NOx was increased in IND+SIT group, as compared to IND group. In conclusion, sitagliptin showed gastroprotective effect in indomethacin induced peptic ulcer in rats mostly through anti-oxidant and anti-inflammatory actions.
Rofaeil, R., & Mohamed, A. (2020). Gastroprotective effect of sitagliptin in experimentally-induced peptic ulcer in rats. Minia Journal of Medical Research, 31(2), 253-256. doi: 10.21608/mjmr.2022.221056
MLA
Remon R. Rofaeil; Asmaa S. Mohamed. "Gastroprotective effect of sitagliptin in experimentally-induced peptic ulcer in rats". Minia Journal of Medical Research, 31, 2, 2020, 253-256. doi: 10.21608/mjmr.2022.221056
HARVARD
Rofaeil, R., Mohamed, A. (2020). 'Gastroprotective effect of sitagliptin in experimentally-induced peptic ulcer in rats', Minia Journal of Medical Research, 31(2), pp. 253-256. doi: 10.21608/mjmr.2022.221056
VANCOUVER
Rofaeil, R., Mohamed, A. Gastroprotective effect of sitagliptin in experimentally-induced peptic ulcer in rats. Minia Journal of Medical Research, 2020; 31(2): 253-256. doi: 10.21608/mjmr.2022.221056
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