Introduction: Diabetes mellitus is an endocrine disorder caused by inherited and/or acquired deficiency in production of insulin by the pancreas, or by the ineffectiveness of the insulin produced which results in increased concentration of glucose in the blood. Diabetic nephropathy (DN) is considered as one of the diabetic complications affecting up to 40% of patients with type 1 or type 2 diabetes. Aim of the study: The aim of our study is to evaluate the level of microRNA-1460a in human serum in diabetic nephropathy in prediabetic and diabetic patients in comparison to the apparent healthy individuals group. Patients and Methods: Subjects: The current study, Acase control study was conducted on 100 persons, 24males (24%) and 76 females (76%) of the same age group (40-65 yrs) were selected from outpatient clinic of diabetes of Internal Medicine Department at Minia University Hospital from June 2017 to June 2018. Results: The serum level of miR‐146a of was significantly increased in diabetic group more than that of the Pre-diabetic and control groups, With p value (< 0.001) . In addition, the levels of circulating serum miR‐146a gradually and markedly increased and was significantly higher in T2DM with macroal-buminuria group than that in T2DM with microal-buminuria ,T2DM with normal-buminuria and control groups. The results revealed that circulating serum miR‐146a was positively correlated to UACR (r = 0.724, p < 0.001), Scr (r = 0.436, p < 0.001) and was nagatively correlated to eGFR (r = −0.450, p < 0.001). Conclousion: We recommend using serum level of miR-146a as new biomarkers for diagnosis of diabetes ,early detection of DN and monitor the progression of DN .
El-Hini, S., El-Akad, A., & Nagib, M. (2020). Study the level 0f micro RNA146 a in human serum in the diabetic patients. Minia Journal of Medical Research, 31(2), 184-188. doi: 10.21608/mjmr.2022.221004
MLA
Sahar H. El-Hini; Atef F. El-Akad; Mariam Y. Nagib. "Study the level 0f micro RNA146 a in human serum in the diabetic patients". Minia Journal of Medical Research, 31, 2, 2020, 184-188. doi: 10.21608/mjmr.2022.221004
HARVARD
El-Hini, S., El-Akad, A., Nagib, M. (2020). 'Study the level 0f micro RNA146 a in human serum in the diabetic patients', Minia Journal of Medical Research, 31(2), pp. 184-188. doi: 10.21608/mjmr.2022.221004
VANCOUVER
El-Hini, S., El-Akad, A., Nagib, M. Study the level 0f micro RNA146 a in human serum in the diabetic patients. Minia Journal of Medical Research, 2020; 31(2): 184-188. doi: 10.21608/mjmr.2022.221004
)
View on SCiNiTO