Histological study on the Effect of Selenium Nanoparticles on Cadmium-induced Thyrotoxicity in Adult Male Albino Rat

Helmy, Dalia H. Abdel-Aziz; Embaby, Azza S. Moawad; Abdel Lattif, Fatma Alzahraa M.; Ali, Mohamed L. Abdel-Aziz

doi:10.21608/mjmr.2022.220857

Histological study on the Effect of Selenium Nanoparticles on Cadmium-induced Thyrotoxicity in Adult Male Albino Rat

Document Type : Original Article

Authors

Department of Medical Histology & Cell Biology, Faculty of Medicine, Beni-Suef University, Egypt

10.21608/mjmr.2022.220857

Abstract

Back ground: Cadmium is a widespread and serious material that leads to different harmful cellular
changes up to death. Se is a well-known element for its antioxidant role in living systems of humans
and animals. Selenium nanoparticles have the ability to act as an antioxidant with reduced risk of
ordinary selenium toxicity. Aim of work: is to investigate the effect of Selenium nanoparticles on
cadmium induced thyrotoxicity in adult male albino rats. Material and methods: A total of 38 adult
male albino rats were divided into four groups. The control group (8 rats) was given only distilled
water for 35 days; the cadmium-treated group was given CdCl2 in their drinking water for 35 days;
the nanoselenium-treated group was given Na2SeO3 in their drinking water for 35 days and the
nanoselenium-cadmium-treated group was given Na2SeO3 and CdCl2 in their drinking water for 35
days. The animals of all groups were sacrificed at the same time and their thyroid glands were rapidly
dissected out. The specimens of each group were processed for light and immunohistochemical
studies. They were stained with hematoxylin and eosin, masson's trichrome, and inducible nitric oxide
synthase. Quantitative morphometric, and statistical studies were performed. Results: Picture of
cytotoxicity was visible in cadmium-treated thyroid sections in the form of disorganized follicles of
varying diameters, with a predominance of smaller follicles. The follicular epithelial cells appeared to
be enlarged and had a vacuolated cytoplasm. In addition to reduced or absent colloid. The thyroid
gland of nanoselenium–cadmium-treated animals showed a nearly normal follicular structure.
Conclusion: In experimental animal the administration of nanoselenium in response to an increased
risk of exposure to cadmium compounds has a protective effect against their harmful effects.

Keywords

Main Subjects