The association of interleukin 6 single nucleotide polymorphism with the susceptibility of Egyptians to HCV infection

Abd El-Baky, Reham M.; Hetta, Helal F.; Fawzy, Michael A.; Fathy, Moustafa

doi:10.21608/mjmr.2022.220847

The association of interleukin 6 single nucleotide polymorphism with the susceptibility of Egyptians to HCV infection

Document Type : Original Article

Authors

¹ Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia, Egypt.

² Department of Microbiology and Immunology, Assuit university, Assuit, Egypt

³ Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia, Egypt

10.21608/mjmr.2022.220847

Abstract

Background: Hepatitis C virus (HCV) is considered as a main leading cause for cirrhosis and hepatocellular carcinoma (HCC). We aimed to examine the association of IL-6 single nucleotide polymorphisms with the susceptibility of Egyptians to HCV infection. Patients and methods: For comparative purposes, four groups were enrolled; chronic HCV (CHC-group, n=22), HCV-related liver cirrhosis (HCV-LC-group, n= 22), HCV-related HCC (HCV-HCC-group, n=54) and an apparently healthy control group (Control-group, n=48). IL-6 rs-1474347 genotyping was performed using real time PCR assays. Results: For IL-6 rs1474347, AA genotype was more frequent in CHC, HCV-LC and HCV-HCC compared to controls. Conclusion: Screening for IL-6 rs 1474347 AC genotype is considered a good marker for testing the susceptibility of Egyptians to be susceptible for HCV infections and the progression of the disease.

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