Introduction: Intraoperative nausea and vomiting (IONV) and Post operative nausea and vomiting (PONV) one of the most distressing anaesthesia-related adverse effects. Aim of the work: The present study aims to evaluate the prophylactic effect of intravenous ondansetron and dexamethasone on decreasing the incidence of nausea and vomiting in parturients undergoing elective caesrean section under spinal anaesthesia. Patients and methods: After approval of the university ethical committee and obtaining informed consent from all patients. This prospective, double-blinded study was conducted in gynecology and obstetric department, El-Minia University Hospital during the period from October 2018 to October 2019, after obtaining approval from the ethical committee and verbal consent from the patients. A total of one hundred and fifty women in child bearing period (18- 45 years) , with BMI of 23-27, height of 150-170 cm and ASA physical status II, who were candidate for elective caesarean, were enrolled in this prospective randomized study. patients were randomly allocated into three groups, 50 patients in each one. Each patient in this study received 5 min preoperatively one of the syringes which containing either: Group A: IV ondansetron 8 mg diluted in 5 ml normal saline. Group B: IV dexamethasone 8 mg diluted in 5 ml normal saline. Group C: 5 ml normal saline The following variables (SBP, DBP, MAP, HR, SpO2) were recorded just before medications (baseline) and intraoperatively also nausea and vomiting was recorded. post operative nausea and vomiting were recorded up to 4 days . Results: Ondansetron and dexamethasone decrease incidence of Nauesa and vomiting. Conclusion: IV administration of 8 mg of ondansetron or 8 mg of dexamethasone 5 minutes before operation were effective in decreasing the incidence of Nauesa and vomiting.
Mohamed, A., Mahran, M., & Ibrahim, R. (2020). Dexamethasone versus ondansetron on post operative nausea and vomiting in caesarean section. Minia Journal of Medical Research, 31(2), 88-96. doi: 10.21608/mjmr.2022.220843
MLA
Ahmed K. Mohamed; Mukhtar M. Mahran; Radwa M. Mohammed Ibrahim. "Dexamethasone versus ondansetron on post operative nausea and vomiting in caesarean section". Minia Journal of Medical Research, 31, 2, 2020, 88-96. doi: 10.21608/mjmr.2022.220843
HARVARD
Mohamed, A., Mahran, M., Ibrahim, R. (2020). 'Dexamethasone versus ondansetron on post operative nausea and vomiting in caesarean section', Minia Journal of Medical Research, 31(2), pp. 88-96. doi: 10.21608/mjmr.2022.220843
VANCOUVER
Mohamed, A., Mahran, M., Ibrahim, R. Dexamethasone versus ondansetron on post operative nausea and vomiting in caesarean section. Minia Journal of Medical Research, 2020; 31(2): 88-96. doi: 10.21608/mjmr.2022.220843
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