Histological Study of Toxic Effects of Acrylamide on the Liver and Kidney of Adult Male Albino Rats

Document Type : Original Article

Authors

Department of Histology, El-Minia Faculty of Medicine

Abstract

Background and objectives: Acrylamide has become one of the important public health concerns as 
it was detected in widely consumed food items; for example, fried bread, potato chips, any 
carbohydrate-rich food products cooked at high temperatures, roasted coffee. Several health hazards 
were reported after acrylamide exposure in animal and human models. Many studies reported that 
acrylamide can induce toxicity to many body organs such as reproductive toxicity, genotoxicity and 
neurotoxicity. Materials and methods: Forty adult male albino rats were randomly divided into 2
groups (n=10 per group). The control group (group I): received only standard diet and drinking 
water for 6 weeks. The acrylamide group (group II): received acrylamide via in tragastric gavage 
route at dose of 20 mg/kg once daily for 6 weeks. Histological and examination of the liver and 
kidney was done. Results: There were marked structural changes in kidney and liver of group II in 
the form of congestion apoptosis and vacuolations if compared to the control group. Conclusion:
Administration of acrylamide continuously for six weeks causes massive destruction in both liver and 
kidney.

Keywords

Main Subjects

Files

Share

How to cite

Statistics