Applying Nanotechnology to improve the Bioavailability of Qurcetine

Document Type : Original Article

Authors

1 Department of Chemical Engineering, Faculty of Engineering, Minia University

2 Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Egypt

Abstract

Many pharmaceutical agents possess low solubility and dissolution behavior. This drawback limited their 
applications in the pharmaceutical field. The aim of this study is to apply nanotechnology to improve the 
physicochemical properties of pharmaceutical agents so as to improve its bioavailability and, hence, its 
therapeutic and clinical activity. Nanoprecipitation technique was optimized in order to obtain 
nanoparticles particles of Quercetin with enhanced solubility and dissolution rate properties. In order to 
attain this target, there are Preparation and physicochemical characterization of Quercetin nanoparticles, 
where nanoprecipitation method was applied to prepare the nanoparticles and different parameters were 
studied to obtain optimum nanoparticles of the drug including, Effect of polymer type , Effect of polymer 
concentration, Effect of homogenization time and Effect of homogenization intensity. On the 
Pharmacokinetic evaluation of the prepared Quercetin Nanoparticles , the optimum drug nanoparticles, as 
well as, the untreated drug was given to rabbits orally in a dose equivalent to 10 mg/kg. Different 
parameters were studied including, The maximum concentration Cmax, The time of maximum 
,concentration Tmax ,The area under plasma concentration-time curve AUC, The area under first moment 
curve AUMC,The elimination rate constant ,The half-life elimination, The absorption rate constant and 
The half-life absorption, Results showed that the prepared nanoparticles produced significant increase in 
the AUC0- (from 113.4 to 341.2 ng/ml.hr) suggesting increasing the bioavailability of the drug. This is 
accompanied with increasing Cmax from (25.2 to 60.4 ng/ml) and slight decrease in the Tmax value to 
1.6 hr.

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