Investigating The variations in The expression level of CEA and TIMP-1 markers in Human Colorectal Carcinoma in Egyptian Patient

Document Type : Original Article

Authors

1 Pharmacist, Ministry of Health, Egypt

2 Department of Biochemistry, Faculty of Pharmacy, Mania University, Egypt

3 Department of Biochemistry, Faculty of Pharmacy, Deraya University, Egypt

4 Department of Biochemistry, Faculty of Medicine, Mania University, Egypt.

Abstract

Background/Aims: In this current study, Our aim is studying verification and confirmation of the 
use of two markers of colorectal cancer in Egyptian patients to discover the disease and diagnose it 
early, because the deaths associated with it are constantly increasing and very worrying, and there are 
previous studies, which some have reported that confirmed the high level of these markers in Blood 
plasma, when colon cancer occurs and some other studies have not been confirmed, and we did this 
study to verify their association with the disease in the presence of an increase in their level in blood 
plasma in Egyptian patients with the disease than healthy people or not related and these two were 
chosen CEA and TIMP-1 because they have found them linked to many different types of cancers 
and we want to work on using them in the early diagnosis of colorectal cancer to avoid death from it 
and improve the diagnosis in the initial stages of its occurrence so that we can quickly cure it and get 
rid of it forever and improve the level of survival rate when an injury occurs in the Egyptian society 
and It has been proven from this study that both the CEA and TIMP-1 concentration is present in the 
blood plasma with an increase in patients than in healthy humans. Materials and Methods: Blood 
samples were collected from eighty-four Egyptian patients. They were categorized into 64 patients 
with CRC: males 45.5% and females 54.5% with age range from 23 to 73 years (Mean ± SD: 45.8 ±
12.4 years); and 20 healthy controls: males 55% and females 45% with age range from 25 to 67 years 
(Mean ± SD: 43.7 ± 10.8 years). Results: A clear increase in the concentration of markers ( CEA, 
TIMP-1) included in the study in blood plasma in patients more than healthy with a wide and clear 
difference, which indicates the correlation of the increase with the presence of the disease 
.Conclusion: It has been verified and confirmed in this study that both markers CEA and TIMP-1 
increase in the case of disease and therefore can be used significantly in detection and the diagnosis of 
the disease early and improve its treatment and recovery from it

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